Saturday, 31 March 2012

So what does this all mean...

The literature regarding the efficacy and recommendation of Veinoplus in the prevention and treatment of venous disease symptoms is not very vast. However, the majority of the studies found were supportive of positive effects using the electrical stimulation device. No research could be found where there were negative side-effects or unfortunate events associated with its application, indicating that it is a safe and effective treatment option.
A major population that is targeted for the use of Veinoplus, as discussed in the above posts, is pregnancy. Le Tohic and colleagues (2011) investigation into the effects of Veinoplus on lower limbs venous insufficiently-related symptoms in pregnancy discovered that the use of the stimulation device was not harmful in any way to the fetus, which is obviously a major factor that comes into play when a mother is deciding upon a treatment of the venous-insufficiency symptoms present with pregnancy.




In response to the previous post regarding the alternative use of compression stockings, it states in the Veinoplus information booklet that in some circumstances, namely treatment of varicose veins, small and large vein post-sclerotherapy, significant venous oedema, post-thrombotic syndrome with a high deep vein thrombosis (DVT) risk and severe symptoms of CVI, the Veinoplus unit is to be used in conjunction with doctor’s prescription and compression garments. This acknowledges the fact that in more severe or progressed venous insufficiency cases a more multi-faceted approach is the best option for the best benefit. This is not stating that Veinoplus is insufficient to get the results it claims to, but that it works superiorly alongside other treatment options.
Compressive garments have long been advised and used for prolonged sitting situations, in particular long flights, but as mentioned in the above blog post these garments also bring with them contraindications for use, including peripheral skin conditions and critical limb ischemia. In terms of patients with severe venous insufficiency issues, it could be suggested that Veinoplus is a more active alternative to be used when on long-haul flights or in prolonged positions, where the use of exercise is also not available.

In regards to obese individuals, Veinoplus may actually pose as a potential safety issue due to the larger current needed to overcome the high resistivity of subcutaneous fat tissue. The accessibility of this device, combined with the general public’s lack of knowledge regarding the potential debilitating effects of electrical stimulation products, increases the risk of unnecessary injuries occurring.
A study by Rij et al. (2008) showed that individuals with obesity actually have a more efficient calf skeletal muscle pump. They attributed these effects to the possibility that obese individuals have more developed calf musculature in order to support their weight. While this may compensate for a small percentage of their venous insufficiency, the lack of exercise and usage of this important physiological mechanism promotes the attainment of a venous pathology.
Therefore, it could be said that the primary treatment for these individuals would be exercise. The previous entry has already alluded to many of the additional benefits of exercise as opposed to Veinoplus. These benefits plus the addition of the safety concerns and an already efficient muscle pump system, make exercise the apparent treatment of choice for obese individuals.



When comparing Veinoplus and exercise, it is also difficult to ignore the fact that by exercising you get the same benefits as Veinoplus therapy along with a vast multitude of other health benefits whilst saving yourself the hiring fee of the Veinoplus unit or the entire $350 to purchase your own unit.
While exercise undoubtedly has its place in the realm of venous insufficiency treatment options, it also comes with certain situations in which other options may be more appropriate. It is widely known and accepted that exercise is a valuable part of healthcare but still adherence levels to adequate levels of exercise remain low in a high percentage of the population (Dishman & Ickes, 1981). This unveils a particular place in the market for Veinoplus in the treatment of those with venous insufficiency who cannot, or refuse to, exercise for treatment.
In conclusion, from the limited clinical trials and reported efficacy of use of Veinoplus, it can be stated that the electrical stimulation therapy device definitely has its place in the treatment arena of venous disease. It is one of a group of treatment options for this population that need to be individually prescribed and suited to the patient and circumstance. To further gain insight into the efficacy of each treatment in comparison with each other, further research needs to be performed. By finding answers to the question of how beneficial one treatment is compared to another, patients suffering venous disease will have a much better way of dealing with their condition in the best way possible for them.

 References
1. Doheny, E.P., Caulfield, B.M., Minogue, C.M. & Lowery, M.M. (2008). The effect of subcutaneous fat thickness on the efficacy of transcutaneous electrical stimulation. Conf Proc IEEE Eng Med Biol Soc. 5684-7.
2. Dishman, R.K & Ickes, W. (1981). Self-motivation and adherence to therapeutic exercise. Journal of Behavioural Medicine, 4(4), 421-438. DOI: 10.1007/BF0084615.  

Tuesday, 27 March 2012

What else could be done?

Veinoplus e-stim therapy is only one therapy targeted at preventing and treating venous disease by improving venous return, reducing venous reflux and peripheral oedema. The main alternative conservative therapy which could be indicated as well as, or instead of, is simply exercise, including avoiding prolonged sitting or standing.



Exercise and the associated skeletal muscle activity increases venous return (Laughlin, 1999), as does Veinoplus therapy in patients with limited or moderate vascular insufficiency. Exercise however, presents with many additional health benefits which clearly indicates it is an appropriate alternative or superior treatment for the same populations Veinoplus is marketed to. Those individuals being those with no contraindications, such as advanced CVD or musculoskeletal injury. 

Additional health benefits which are associated with exercise, but not Veinoplus therapy include:
  • Decreased hypertension,
  • Improved glucose metabolism & insulin sensitivity
  • Important factor in weight loss
  • Improved blood lipid levels
  • Decreased thrombosis formation (increased fibrinolytic ability)
  • Improved endothelial function
  • Improved autonomic nervous system function (Shepard et al, 1999).

As previously mentioned, exercise is supported by literature in general (Boccalon, 1999) as an effective and viable option, for assisting to prevent venous disease or similar symptoms associated with impaired venous return, all of which are indications in each of Veinoplus's target populations.

Exercise in pregnant populations has been recommended for those without pregnancy complications to provide all the same benefits as in general populations, as well as numerous additional benefits targeted at common pregnancy consequences, including reduction of leg oedema (Duckitt, 2011). An article by Debert (2011) also included prevention of blood clots (VTEs) and varicose veins as benefits of exercising during pregnancy. A common benefit was mentioned in the previous post regarding the use of Veinoplus in pregnancy for VTE prevention.

As with pregnancy, exercise is clearly important and indicated for obese populations due to the numerous health benefits including the support of weight loss (Okay, Jackson, Marcinkiewicz & Papino, 2009). Because obesity is a recognised risk factor for decreased venous function, by promoting weight loss and exercise, it assists in the prevention and treatment of venous disease. This additional weight loss effect that comes with exercise is arguably a great selling point for exercise over Veinoplus in the prevention and treatment of venous disease.



Veinoplus and exercise both represent therapies which are more preventative of venous diseases and treatment for venous symptoms such as leg oedema or the increased risk of VTEs associated with pregnancy. As mentioned in the second paragraph of this post, these are beneficial treatments for limited to moderate conditions. In the case of moderate to severe venous conditions and associated VTEs, an example of which is displayed in the above image where the patient has stasis pigmentation due to severe venous insufficiency, the treatment is more focused towards drug therapy with anticoagulant, venous surgery and endoluminal venous abalaton, depending on the specific pathology (McLafferty, 2006).


An important venous disease preventative and treatment therapy not yet discussed, or compared to Veinoplus, is compression therapy which is achieved by applying graduated compression stockings (GCS) to the at risk patient. This external compression of the legs replaces the compression caused by skeletal muscle with Veinoplus or exercise therapies and results in:
  • Preventing venous stasis (promoting venous blood flow velocity)
  • Preventing vessel injury
  • Preventing coagulation (Joanne Briggs Institute, 2001). 
A study by Zajkowski et al (2002) found that in patients with venous insufficiency, GCSs were more effective at preventing venous reflux than improving skeletal muscle pump action; however this is still a positive indication for use. A literature review by Xo (2010) concluded that the use of GCSs were indicated in those patients with increased risk factors for deep vein thrombosis and to combat dependant oedema but also that their use was fraught with many contraindications including peripheral skin conditions and critical limb ischemia and thus must be prescribed and applied with caution.



In summary there are a number of alternative therapies to Veinoplus which produce the same results, leaving us with the question is Veinoplus, at $350 unit, a practical and realistically competitive option for prevention of leg oedema and venous disease?

References


1. Boccalon, H. (1999). Venous disease. International Angiology, 18(1), 15-16

2. Debert, C. (2011). Exercising during pregnancy. Family Health, 27(1), 22-23

3. Duckitt, K. (2011). Exercise during pregnancy. British Medical Journal, 343, d5710

4. Joanna Briggs Institute. (2006). Graduated compression stockings: prevention of postoperative venous thromboembolism is crucial. American Journal of Nursing, 106(2), 72AA- 72DD

5. McLafferty, R.B. (2006). Office-based treatment of venous disease. Perspectives in Vascular Surgery and Endovascular Therapy, 18(4), 306-310, DOI: 10.1177/1531003506297364

6. Okay, D.M., Jackson, P.V., Marcinkiewicz, M., & Papino, M.N. (2009). Exercise and obesity. Primary Care: Clinics in Office Practice, 36, 379-393, DOI: 10.1016/j.pop.2009.01.008

7. Shepherd, R.J., & Balady, G.J. (1999). Exercise as cardiovascular therapy. Journal of the American Heart Association: Circulation, 99(7), 963-972, DOI: 10.1161/01.CIR.99.7.963

8. Xu, B. (2010). DVT in acute stroke - the use of graduated compression stockings. Australian Family Physician, 39(7), 485-487

9. Zajkowski, P.J., Proctor, M.C., Wakefield, T.W., Bloom, J., Blessing, B., & Greenfield, L.J. (2002). Compression stockings and venous function. Archives of Surgery, 137(9), 1064-1068

Thursday, 15 March 2012

How does it work?

As previously described, Veinoplus is an electrotherapeutic device that increases venous return to the heart. It’s mechanism of action is via the administration of electrical impulses to the musculature around the calves, thus causing excitatory stimulation of motor neurons. The activation of these motor neurons causes muscle contraction and relaxation, promoting venous return. This is otherwise known as a skeletal muscle pump.

The skeletal muscle pump mechanism works on the theory that contraction and relaxation of the calf muscles will compress the intramuscular veins causing an upwards movement of blood towards the heart. This is due to the valvular nature of the veins, which only allows unidirectional blood flow.



Veinoplus is administered at:

  • Modulated frequency from 1 to 250Hz (within the electrical stimulation range)
  • Biphasic symmetrical waveform to ensure no accumulation of charge within the tissues (Instruction Manual)
  • Variable number of daily sessions - ranging from 1 - 3/day and 20 minute sessions (Li Tohic, Bastian, Pujo, Beslot, Mollard & Madelenat, 2008; Bogachev, Golovanova, Kuznetsov, Shekoyan & Bogacheva, 2011).
  • Electrode placement is bilateral, with one electrode on each calf muscle simultaneously. This may appear conflicting to other set-ups of electrical stimulation where electrodes placed bilaterally is advised against, due to the current potentially flowing through the heart. In Veinoplus' case, it is clinically proven to be safe and effective using this electrode placement, even in pregnant women, presumably due to the very low quantities of electrical energy produced (Instruction manual).
Personal experience with the Veinoplus device confirmed the ease of use for the general population and patients who will benefit. Application of the device involves electrode placement on both calves with self-ashesive electrodes which are easy to apply. It is then a matter of connecting the electrodes to the handheld machine, pressing on and increasing the intensity (+ button) until you feel a deep muscular pulsation. The sensation may differ between legs, therefore intensity should be adjusted based upon the more sensitive limb. It appeared that if the intensity was increased too much, a tingling sensation is felt into the toes. In this case, the intensity should be reduced to a comfortable level.



So who will benefit most from Veinoplus therapy?



Pregnant women
Research shows that pregnant women are at greater risk of developing venous pooling due to their hypercoagulative state.These women have a greater amount of coagulation factors and decreased fibrinolytic activity, thus decreasing their venous flow velocity in the lower limbs by up to 50% (Marik, P. 2010). Although this may appear abnormal or scary to pregnant woman, it has been stated that these vascular changes and the presence of lower limb odema are healthy and normal consequences of the increase in hydration, naturally occurring with pregnancy (Robertson, 1971). As pregnant women are unable to exercise as regularly as their non-pregnant counterparts, the use of Veinoplus may be advantageous for initiating the skeletal muscle pump mechanism, preventing thrombus formation within the slow moving blood by increasing flow velocity. (http://www.thebabycorner.com/page/2562/)


Obesity
Individuals who are obese have been shown to have decreased venous function. This is due to increased abdominal pressures measured in those with obesity forcing more blood into the lower extremities and making it more difficult for blood to overcome the pressure gradient towards the heart. The weight of the abdomen and the mass of the visceral fat could also contribute to decreased venous function by impinging on the veins in the pelvis and groin (Rij, Alwis, Jiang, Christie, Hill, Dutton & Thomson, 2008).

Prolonged sitting or standing                                   
In these states, individuals are not activating their calf-muscle pumps thus slowing the velocity of the blood within the lower limbs. If the blood moves too slowly, it can cause improper closure of the valves leading to venous backflow and pooling. This greatly increases an individuals risk of developing a DVT. This is especially true in situations such as long-haul flights where individuals are more inactive and environmental factors such as reduced air pressure contribute to increased venous stress (Ball, K. 2003). http://www.copterplane.net/2012/aeroplane/

Hormone Therapy
Exogenous eostrogens may increase risk of venous thromboembolism (VTE) by altering the balance of coagulation factors and coagulation inhibition (Lowe, G. 2004). Thus, Veinoplus can ensure blood flow velocity is maintained so that VTE’s are less likely to form.








 References
1.  Ball, K. (2003) Deep Vein Thrombosis and Airline Travel—The Deadly Duo, AORN Journal. 77(2). 346-354. http://search.proquest.com.libraryproxy.griffith.edu.au/docview/200833315


2. Bogachev, V.Y., Golovanova, O.V., Kuznetsov, A.N., Shekoyan, A.O. & Bogacheva, N.V. (2011). Electromuscular stimulation with VEINOPLUS for the treatment of chronic venous edema. International Angiology, 30(6), 567-570.

3. Li Tohic, A., Bastian, H., Pujo, M., Beslot, P., Mollard, R. & Madelenat, P. (2009). Effects of electrostimulation (Veinoplus) on lower limbs venous insufficiency-related symptoms during pregnancy: Preliminary study. Gynecol Obstet Fertil, 37(1),18-24.
4. Lowe, G. (2004) Hormone Replacement Therapy and Cardiovascular disease: Increased Risks of Venous Thromboembolism and Stroke, and No Protection from Coronary Heart Disease, Journal of Internal Medicine, 256(5), 361-374, doi: 10.1111/j.1365-2796.2004.01400

5. Marik, P. (2010) Venous Thromboembolism in Pregnancy, Clinics in Chest Medicine, 31(4), 731-740, doi:10.1016/j.ccm.2010.06.004


6.  Rij, A. & Alwis, C. & Jiang, P. & Christie, R. & Hill, G. & Dutton, S. & Thomson, I. (2008) Obesity and Impaired Venous Function, European Journal Of Vascular and Endovascular Surgery, 35(6), 739-744, doi:10.1016/j.ejvs.2008.01.006

7. Robertson, E.G. (1971). The natural history of oedema during pregnancy. BJOG: An International Journal of Obstetrics & Gynaecology, 78, 520–529. doi: 10.1111/j.1471-0528.1971.tb00310.x



Thursday, 8 March 2012

Veinoplus... What is it?


http://en.wikipedia.org/wiki/Veinoplus

Veinoplus is an example of a specific brand of an electrostimulation agent used for the treatment of Venous Disease, throughout a range of different disease levels. The device's website and user manual states that Veinoplus has clinically proven results in both prevention and care at varying levels of the 'Venous Disease Cascade'.


So what exactly is Venous Disease?
Venous Disease refers to a range of disease states that have a central component of damaged or abnormal veins which results in a reduced ability to pump blood back to the heart and an increase in venous pressure. This increase in venous pressure further stretches the veins and increases the backflow of blood, with possible 'leakiness' of the veins. A common result of the venous insufficiency is odema, commonly referred to as swelling, of the lower limbs (1).


Risk factors for Venous Disease include:
  • Pregnancy
  • Obesity
  • Prolonged standing
  • Illness
  • Surgery
  • Previous history of blood clotting
(Heit, Silverstein, Mohr, Petterson, O'Fallon & Melton III, 2000)

Some examples of venous disease that Veinoplus particularly helps are venous hypertension, chronic reflux, ulcers and odema (2).

Circumstances in which the use of Veinoplus is contraindicated include:
  • Implanted cardiac pacemakers
  • Patients undergoing anti-cancer therapy
Use in the following situations should be proceeded with caution:
  • Acute venous thrombosis
  • Tendency to bleed induced by anti-clotting treatment
  • Sciatica or any other neuralgia
  • Inflammation, infection, skin lesions or severe varicose veins (in which electrodes can be placed next to, but not on, the affected area.
  • Only use on legs and possibly arms, not any other body parts. (Instruction manual).

The Veinoplus machine is easily accessible and safe for the target audience. It is available to purchase online, accessible from the OAPL catalogue (3) at a price of approximately $350. It is pocket sized, safe and realitvely simple to use. It is an electrostimulation device that triggers deep calf muscles contractions in order to aid venous return to the heart. It is said to be clinically proven at improving the symptoms of Venous Disease. Although the website says it is clinically proven, the extent of the literature is certainly not vast.

The products website has a comprehensive overview of the product, including an acronym for its action, PROPER as shown below:
  • PUMPING: Results in a rapid decrease of blood volume in lower limb veins and resultant removal of blood stasis.
  • REFLUX: Inhibits reflux in deep and superficial veins.
  • OUTFLOW: Significantly alters venous outflow from lower limbs (volume and velocity).
  • PAIN: Immediate and long-lasting analgesic effect.
  • EDEMA: Reduces odema in those patients with venous insufficiency.
  • REMAINS: Produces an effect that remains and improves user's quality of life.
References:


2. http://www.veinoplus.com/ 


3. http://www.oapl.com.au/Physiotherapy_Catalogue_V2.10(web).pdf


4. Heit, J.A., Silverstein, M.D., Mohr, D.N., Petterson, T.M., O'Fallon, M. & Melton III, J. (2000). Risk factors for deep vein thrombosis and pulmonary embolism. A population-based case-control study. Arch Intern Med, 160, 809-815.